Although plasma medicine has been established as a promising approach in the medical field, many challenges still threaten this promising field to move forward, such as clarification of the mechanisms involved in the therapeutic action of plasmas and plasma-conditioned liquids, insufficient standardization, or an urgent need for enhanced dialogue and interaction between scientists, medical doctors or industry among others. In September 2021, the COST Action Therapeutical applications of Cold Plasma (PlasTHER), set up its collaborative network of specialists designed to coordinate European activity in this domain and promote the development of a coherent European research programme.