CREB researchers have made a critical assessment of the recent progress made in the application of 3D printing technologies for bone regeneration, focusing especially on the design of personalized bone grafts. They highlight the possibility to incorporate pharmaceutics into the bone grafts and the analyze the advances in the translation of the 3D printing technology to the biomedical industry and the clinics. Upcoming advances in commercial 3D-printed bone grafts are expected following recent research advances, aiming at mimicking better and better the natural bone at different levels. Another field of improvement is related to biological performance. Although most current 3D-printed ceramic grafts present excellent biocompatibility, they are still far from the performance of natural bone.